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Guidance on the assessment of iMCD for pathologists

REGRESSED GERMINAL CENTRES (GCs)

Grade 2–3 regressed GCs are considered diagnostic. Please see below for examples supported by written guidance from a member of our expert panel.

Grade 1
(few regressed GCs)
Expand
Grade 3
(most regressed GCs)
Expand
STEP 1

Abbreviations

GCs, germinal centres.

This tool has been funded and produced by Recordati Rare Diseases (RRD). All images have been provided by an international panel of expert pathologists.
The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.

Prescribing Information
Adverse events should be reported. (UK) Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/. (Ireland) Healthcare professionals are requested to report suspected adverse reactions to HPRA via their website https://www.hpra.ie/. Adverse events should also be reported to Recordati UK Ltd by telephone: +44 (0)1491 414 333 or email: RRDpharmacovigilance@recordati.com.

IE-SYL-0103
May 2025

This website is developed by Recordati Rare Diseases (RRD) and is intended for use by healthcare professionals only.
For more information, please contact us at: Email: RRDUnitedKingdominfo@recordati.com Mailing address: Recordati UK Ltd, Breakspear Park, Breakspear Way, Hemel Hempstead HP2 4TZ, United Kingdom
Company reg no: 09329429.
  • H&E

EXPERT GUIDANCE

Regressed GCs: Grade 3

This H&E section of a cervical lymph node shows small atrophic germinal centers with depletion of centrocytes and centroblasts. This is a feature of chronic immune stimulation as seen in chronic viral infections, auto-inflammatory disorders, but also of iMCD.

Abbreviations

GCs, germinal centres; H&E, hematoxylin and eosin; iMCD, idiopathic Multicentric Castleman Disease.

This tool has been funded and produced by Recordati Rare Diseases (RRD). All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.

  • H&E

EXPERT GUIDANCE

Regressed GCs: Grade 1

This H&E section of a cervical lymph node shows a conserved compartimentalization between B- and T-cell areas. The large majority of the follicles show normal size and composition.

Abbreviations

GCs, germinal centres; H&E, hematoxylin and eosin.

This tool has been funded and produced by Recordati Rare Diseases (RRD). All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.

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