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Guidance on the assessment of iMCD for pathologists

FOLLICULAR DENDRITIC CELL PROMINENCE

Grade 1
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Grade 3
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STEP 1

This tool has been funded and produced by Recordati Rare Diseases (RRD). All images have been provided by an international panel of expert pathologists.
The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.

Prescribing Information
Adverse events should be reported. (UK) Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/. (Ireland) Healthcare professionals are requested to report suspected adverse reactions to HPRA via their website https://www.hpra.ie/. Adverse events should also be reported to Recordati UK Ltd by telephone: +44 (0)1491 414 333 or email: RRDpharmacovigilance@recordati.com.

IE-SYL-0103
May 2025

This website is developed by Recordati Rare Diseases (RRD) and is intended for use by healthcare professionals only.
For more information, please contact us at: Email: RRDUnitedKingdominfo@recordati.com Mailing address: Recordati UK Ltd, Breakspear Park, Breakspear Way, Hemel Hempstead HP2 4TZ, United Kingdom
Company reg no: 09329429.
  • H&E
  • CD21

EXPERT GUIDANCE

Follicular dendritic cell (FDC) prominence: Grade 3

This secondary follicle shows depletion of B-cells and a prominent proliferation of FDCs. The proliferation is very obvious when performing a CD21 immunostain.

Abbreviations

FDCs, follicular dendritic cells; H&E, hematoxylin and eosin.

This tool has been funded and produced by Recordati Rare Diseases (RRD). All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.

  • H&E

EXPERT GUIDANCE

Follicular dendritic cell (FDC) prominence: Grade 1

FDCs are present in primary and secondary B-cell follicles and play an important role in the antigen presentation to maturing B-cells. They form a network with their arborizing process. In this secondary germinal center there are very sparse follicular dendritic cells. They are characterised by 1 or 2 large round vesicular nuclei with a solitary central nucleolus. The dendritic process can be illustrated by immunohistochemistry against CD21, CD23, CD35 or podoplanin.

Abbreviations

FDCs, follicular dendritic cells; H&E, hematoxylin and eosin.

This tool has been funded and produced by Recordati Rare Diseases (RRD). All images have been provided by an international panel of expert pathologists. The concept, functionality and expert guidance found within this tool has also been developed with the support of expert pathologists.

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